One particular area of interest is in milk thistle's ability to protect and perhaps restore the liver. People may also find it painful and worry about its effects on their appearance. Milk thistle is found throughout the eastern United States, California, South America, Africa, Australia, and Asia. 2017 Apr;42(4):1073-1083. doi: 10.1007/s11064-016-2141-4. Its been suggested that oxidative stress in the body may play a role in the development of acne (41). If left untreated, anaphylaxis can lead to shock, coma, cardiac or respiratory failure, or even death. National Cancer Institute PDQ Integrative, Alternative, and Complementary Therapies Editorial Board. Hepatology. Questions? . In clinical trials, milk thistle appears to be well tolerated in recommended doses. 2016;5147468. doi:10.1155/2016/5147468. 5-Methyltetrahydrofolate Alleviates Memory Impairment in a Rat Model of Alzheimer's Disease Induced by D-Galactose and Aluminum Chloride. Receive the latest, most useful health and wellness articles, tips, special discounts on nutritional supplements and so much more. "It helps to clear out the toxins and nourish the organ," says Justice. However, many of these potential benefits are not backed by science. Milk thistle can cause an allergic reaction, including a severe, potentially life-threatening allergic reaction (anaphylaxis). 2016;2016:5147468. doi:10.1155/2016/5147468, Dietz BM, Hajirahimkhan A, Dunlap TL, Bolton JL. Summary In animals, milk thistle has been shown to stimulate bone mineralization. Large-scale, properly-designed studies are needed. Risks. Benefits. 2 skintightspandex 3 yr. ago Ya idk I've taken milk thistle for liver health and I have anxiety independent of it Nootropicsfan 3 yr. ago All rights reserved. Milk thistle might also help prevent insulin resistance and slow the growth of cancer,. When considering the use of herbal supplements, seek the advice of your doctor. And, most recently, milk thistle is gaining traction as a natural remedy to help manage the symptoms of OCD. Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID-19, plus expertise on managing health. One important detoxifying ingredient is milk thistle. Closer to a Cancer Cure? Call your doctor if the condition you are treating with milk thistle does not improve, or if it gets worse while using this product. Its also unknown what doses would need to be prescribed for it to have a beneficial effect (18). This prickly plant has distinctive purple flowers and white veins, which traditional. Milk thistle (silymarin) is a flowering herb related to the daisy and ragweed family. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Elsevier; 2021. https://www.clinicalkey.com. However, the studies in humans are very limited and have yet to show a meaningful clinical effect in people (32, 33, 34, 35, 36). Talk with your healthcare provider before starting milk thistle to make sure it is the right supplement for you. JAMA. We comply with the HONcode standard for trustworthy health information. Swimming and L-arginine loaded chitosan nanoparticles ameliorates aging-induced neuron atrophy, autophagy marker LC3, GABA and BDNF-TrkB pathway in the spinal cord of rats. One study questioned the benefits of milk thistle for liver diseases. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. information is beneficial, we may combine your email and website usage information with If you are a Mayo Clinic patient, this could . Epub 2023 Mar 4. The survey revealed anecdotal evidence of the improved quality of life among those who took milk thistle, despite having no measurable improvements in hepatitis symptoms like liver inflammation. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. The best doses of milk thistle have not been established for any condition it may be used to treat. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Skip the missed dose if it is almost time for your next scheduled dose. Some of the studies have been of poor quality, too. Our website services, content, and products are for informational purposes only. This content does not have an English version. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Learn more about natural remedies for type 2 diabetes. Pharmacol Rev. Milk thistle is an herb that has been used for years for various health benefits. However, there are currently no human studies examining the effects of milk thistle in people with Alzheimers or other neurological conditions like dementia and Parkinsons. World J Gastroenterol. Some studies also show milk thistle may help people whose liver is damaged by industrial toxins, such as toluene and xylene. eCollection 2022. #1: Milk thistle detoxifies the liver. A double-blind controlled study. You may also consider consulting a practitioner who is trained in the use of herbal/health supplements. This site needs JavaScript to work properly. Some people have nausea, diarrhea, itching, and bloating. 2023 Jan 26;15:997054. doi: 10.3389/fnmol.2022.997054. Uses of Lavender: Everything You Need to Know, 11 Popular Natural Remedies for the Common Cold, Natural Remedies for Alcohol Use Disorder, The therapeutic potential of milk thistle in diabetes, Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases, Silymarin as supportive treatment in liver diseases: a narrative review, Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial, Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial, Effects of Silybum marianum (L.) Gaertn. Fluoxetine (Prozac), for instance, clocks in at roughly $16 for 21 capsules if youre buying with the drugs.com discount card, but the side effects are often not as easy to swallow (3). Phytother Res. Seeff, L.; Curto, T.; Szabo, G. et al. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. If you have diabetes, use milk thistle with caution, since the supplement might lower blood sugar. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. From aloe to honey, you might be surprised what basic ingredients can help improve breakouts. Dosage and side effects. Medical research suggests that milk thistle, combined with traditional treatment, can improve diabetes. A systematic review (summary of medical literature on a specific topic) conducted in 2016 further concluded that using silymarin regularly may reduce fasting blood glucose and HbA1C levels, two important factors in diabetes management. Its unclear what benefits, if any, it may have in the body, but its sometimes used as a natural treatment for things including cirrhosis, jaundice, hepatitis, and gallbladder disorders. It also states that Milk Thistle will lower Ferritin and that iron-supplement is advised. Cookies collect information about your preferences and your devices and are used to make the site work as you expect it to, to understand how you interact with the site, and to show advertisements that are targeted to your interests. Milk thistle is primarily taken in supplements sold as tablets, capsules, or extract primarily to help with liver function. 2007 Sep;10(9):1089-93. doi: 10.1038/nn1971. These studies have also seen that milk thistle may be able to reduce the number of amyloid plaques in the brains of animals with Alzheimers disease (18, 19, 20). There is a problem with Milk thistle is native to Europe and was introduced into North America by early colonists. 2020 Feb;47(2):302-312. doi: 10.1111/1440-1681.13201. Luckily, more and more experts are turning to natural remedies to answer that question and circumvent the litany of side effects. It is not intended to substitute for the medical expertise and advice of your health care provider(s). Consult with a licensed healthcare professional before using any herbal/health supplement. The Clearinghouse does not provide medical advice, treatment recommendations, or referrals to practitioners. Silymarin, a milk thistle element, is reported safe at doses of 700 milligrams three times a day for 24 weeks. Review/update the What Is Complementary, Alternative, or Integrative Health? I think milk thistle is often used in combo with NAC to enhance it's beneficial effects. Summary One study has shown that people taking milk thistle supplements experienced a decrease in the number of acne lesions on their body. Milk thistle is effective at naturally reversing toxicity in the body, including the harmful . Borah A, Paul R, Choudhury S, Choudhury A, Bhuyan B, Das Talukdar A, Dutta Choudhury M, Mohanakumar KP. Endo-Lysosomal and Autophagy Pathway and Ubiquitin-Proteasome System in Mood Disorders: A Review Article. All rights reserved. This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply. Milk thistle is promoted as a dietary supplement for . No supplement is intended to treat, cure, or prevent disease. Summary Milk thistle extract may help protect the liver against damage caused by disease or poisoning, though more research is needed. There is no standardized dosage or recommended intake for milk thistle tea, but it's generally considered safe if consumed in moderation. Accessed Oct. 30, 2020. Effect of silymarin on biochemical indicators in patients with liver disease: systematic review with meta-analysis. What Are the Side Effects of Milk Thistle? Milk thistle may be a useful complementary therapy to help manage type 2 diabetes. Milk thistle and its antioxidant properties are promising in managing OCD symptoms but it may also be beneficial to explore other herbs for OCD treatment to bolster and round out a supplement regimen. We know little about whether milk thistle is effective in people, as only a few well-designed clinical studies have been conducted. Keep in mind that supplement use should be individualized and vetted by a healthcare professional, such as a registered dietitian, pharmacist, or healthcare provider. Careers. Brain Fog (anxiety, depression, ADHD), lots of medications. Not only does this help prevent cirrhoris, but may also be advantageous for those living with hepatitis or other liver diseases. UltraThistle, the highest potency milk thistle formula, has been scientifically proven to be up to 10x more absorbable and up to 20x more effective than other standardized milk thistle formulas. Version: 2.01. Milk thistle is thought to be safe for most people, but precautions should be taken as side effects are possible. Medicinal use of this product has not been approved by the FDA. About curcumin, it isn't usually a problem but if you're on IMAOs you may like to read a bit before taking high doses. Milk thistle is sometimes used to treat skin conditions including mild psoriasis. Milk thistle can trigger allergic reactions. Website: https://pubmed.ncbi.nlm.nih.gov/. Multiple Myeloma vs. Leukemia: What Are the Differences? Song X, Zhou B, Zhang P, Lei D, Wang Y, Yao G, Hayashi T, Xia M, Tashiro S, Onodera S, Ikejima T. Neurochem Res. Botanicals and their bioactive phytochemicals for women's health. Summary Milk thistle may help lower blood sugar levels in people with type 2 diabetes, though more high-quality studies are needed. JAMA. If youre pregnant or breastfeeding, check with your doctor before using milk thistle. Join 45,000+ subscribers and receive the latest, useful and exclusive health and wellness articles, health tips, special offers and more - delivered direct to your inbox. Milk thistle has not been shown to treat or prevent cancer or reduce the side effects of cancer treatment. Take charge of your healthtalk with your health care providers about any complementary health approaches you use. CNS Neurosci Ther. By using our site, you acknowledge that you have read and understand our. Herbal product use by persons enrolled in the Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. Researchers believe that silymarin reduced the oxidative stress traditionally attributed with diabetes (7). Natural Medicines Comprehensive Database: "Milk Thistle Monograph. Do not use this product without medical advice if you are breast-feeding a baby. Biomed Pharmacother. As a liver support and liver aid, milk thistle acts as a powerful liver cleanser by rebuilding liver cells, reducing liver damage and removing toxins from the body that are processed through the liver. In trying to determine the proper milk thistle OCD dosage, herbalists and experts tend to recommend 200-400mg divided across two or three doses per day (5). Liver Detoxification and Health. It may be effective in mild to moderate depression, but two studies reported no benefit in major depression . By lowering LDL "bad" cholesterol levels, milk thistle may lower the chance of developing heart disease. However, this review also noted that the quality of the studies was not very high, so more studies are needed before its possible to make any firm recommendations (44). It usually develops slowly over a number of years and causes weak and fragile bones that break easily, even after minor falls. Milk thistle may produce allergic reactions, which tend to be more common among people who are allergic to plants in the same family (for example, ragweed, chrysanthemum, marigold, and daisy). The benefits of milk thistle are believed to come from silymarin, an anti-inflammatory compound present throughout the entire plant, but highly concentrated in milk thistle seeds (4). ODS seeks to strengthen knowledge and understanding of dietary supplements by evaluating scientific information, supporting research, sharing research results, and educating the public. Mol Med Rep. 2016;13(4):3243-8. doi:10.3892/mmr.2016.4887, Yang Z, Zhuang L, Lu Y, Xu Q, Chen X. Abstract Depression is one of the most frequent psychiatric disorders of Alzheimer's disease (AD). Malaria. It can be consumed in supplement form or as a tea. Satisfaction. Do not use different forms (tablets, liquid, extract, teas, etc) of milk thistle at the same time without medical advice. Consult with your healthcare provider if you experience these and other side effects to find out the best way to proceed. There's limited evidence, though, for the role of milk thistle in bone health. Her work is regularly featured in media such as First For Women, Woman's World, and Natural Health. 2021;142:112024. doi:10.1016/j.biopha.2021, Walsh JA, Jones H, Mallbris L, et al. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. 1. https://iocdf.org/about-ocd/ocd-treatment/meds/, International OCD Foundation, Medications for OCD, By By Michael Jenike, MD, Retrieved May 5, 2019, 2. https://theoakstreatment.com/blog/ocd-facts-and-statistics/, The Oaks Treatment, OCD Facts and Statistics, Published June 18, 2018, Retrieved May 5, 2019, 3. https://www.psycom.net/ocd-medication-guide/, Psycom.net, OCD Medication Guide, By Kathleen Smith, PhD, Last Updated September 21, 2018, 4. https://www.ncbi.nlm.nih.gov/pubmed/20564545, Phtotherapy Research, Milk thistle in liver diseases: past, present, future, Published October 24, 2010, Retrieved May 5, 2019, 5. https://www.drugs.com/npp/milk-thistle.html, Drugs.com, Milk Thistle, Last updated on Mar 1, 2019, Retrieved May 5, 2019, 6. https://www.verywellhealth.com/the-benefits-of-milk-thistle-88325, VeryWellHealth.com, The Benefits of Milk Thistle, By Kathee Wong, Updated March 08, 2019, Retrieved May 5, 2019, 7. https://linkinghub.elsevier.com/retrieve/pii/S0944711315000227, Phytomedicine, Effects of Silybum marianum (L.) Gaertn. 7 likes, 2 comments - lyndsey | nutrition + fertility + herbalism + birth (@rooted_in_ritual) on Instagram: " Ways to Prepare for Ovulation Ovulation is the . However, the evidence is conflicting. Ask a doctor, pharmacist, or other healthcare provider if it is safe for you to use this product if you have: an allergy to plants such as ragweed, chrysanthemums, marigolds, or daisies. Call your doctor for medical advice about side effects. Common side effects of milk thistle may include: indigestion, bloating, gas, stomach pain; This is not a complete list of side effects and others may occur. Milk thistle can cause: Gastrointestinal issues, such as diarrhea, constipation, nausea, vomiting and abdominal bloating Itchiness Headache If you have diabetes, use milk thistle with caution, since the supplement might lower blood sugar. An official website of the United States government. Facts & Comparisons eAnswers. Data sources include IBM Watson Micromedex (updated 2 Apr 2023), Cerner Multum (updated 17 Apr 2023), ASHP (updated 10 Apr 2023) and others. But the evidence is limited, and some research methodologies are flawed, so its difficult to confirm these effects. Eighteen clinical trials of 1,088 participants were assessed. Milk thistle is a popular herbal remedy best known for its liver-protecting properties. Its unclear if milk thistle has the same effects in people without diabetes. PMC 1982;17:51721. Together, you can make shared, well-informed decisions. When looking at Milk Thistle itself (prior to any extraction), the fruits or thistles contain: Silymarin at 1.5-3% of dry weight (to be elucidated later) [2] Silyhermin and both Neosilyhermin A and B [2]; Protein and Mucilage (taking up 25-30% of the herb by dry weight) [2] Quercetin and the dihydro varient known as Taxifolin [2]; Kaempferol, Dihydrokaempferol, and the 7-glucoside and 3 . 2012;308(3):274-282. doi:10.1001/jama.2012.8265, Ebrahimpour koujan S, Gargari BP, Mobasseri M, Valizadeh H, Asghari-jafarabadi M. Effects of Silybum marianum (L.) Gaertn. Abstract Allergic asthma is a chronic inflammatory disease regulated by coordination of T-helper2 (Th2) type cytokines and inflammatory signal molecules. This may be because people arent able to absorb enough to get a medicinal effect. People who are allergic to artichokes, kiwi, ragweed, daisies, marigolds, and chrysanthemums are at higher risk.
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